Unable to get property 'UI'

We are moving a website from VS 2010 .Net 4.0 to VS 2015 .net 4.5.2 and we are getting the error below when we click on a record to edit in a ListView.  The edit template also includes an embedded GridView as I show below.  All works fine on old website.  The GridView is using a NumericUpDownExtender as part of the 4.0 Ajax Toolkit and appears to be the source of the problem.  If anything more is needed to help troubleshoot this issue I will be glad to add any more details.  The error message is below.

"Unable to get property 'UI' of undefined or null reference"

Sys.Application.add_init(function() {$create(Sys.Extended.UI.NumericUpDownBehavior, {"Maximum":1.7976931348623157E+308,"Minimum":0,"RefValues":"","ServiceDownMethod":"","ServiceDownPath":"/ketodiet/clients/Meals","ServiceUpMethod":"","Tag":"","TargetButtonDownID":"IBtnDown","TargetButtonUpID":"IBtnUp","Width":20,"id":"NumericUpDownExtender2"}, null, null, $get("txtActGrams"));
});"Unable to get property 'UI' of undefined or null reference<asp:GridView ID="gvActualFoods" runat="server" AutoGenerateColumns="False" 
    DataSourceID="SqlselActualFoodsClient" ShowFooter="True" 
    OnRowDataBound="gvActualFoods_RowDataBound" 
    OnPreRender="gvActualFoods_PreRender"
    GridLines="Horizontal" RowStyle-BorderStyle="Solid" 
    RowStyle-BorderWidth="1pt" RowStyle-BorderColor="White"><RowStyle BorderColor="White" BorderStyle="Solid" BorderWidth="1pt" VerticalAlign="Top" /><HeaderStyle BorderStyle="Solid" BorderColor="White" BorderWidth="1pt" Font-Bold="False" CssClass="gridhead" /><FooterStyle BorderStyle="Solid" BorderColor="White" BorderWidth="1pt" /><Columns><asp:TemplateField HeaderText="Del&nbsp;" ItemStyle-HorizontalAlign="Center"><ItemTemplate><asp:CheckBox ID="ckDelete" runat="server" TabIndex="-1" onclick="setChange();" /></ItemTemplate></asp:TemplateField><asp:TemplateField HeaderText="Food Item" HeaderStyle-Wrap="False" ItemStyle-Wrap="True"><ItemTemplate><asp:Label ID="LblFoodItem" runat="server" Text='<%# Eval("FoodItem") %>' Width="120"></asp:Label></ItemTemplate></asp:TemplateField><asp:TemplateField HeaderText="Grams"><ItemTemplate><asp:TextBox ID="txtActGrams" runat="server" Text='<%# Bind("ActGrams") %>' Width="28"
                    onkeydown="setChange();" onchange="showsave();calcfoods(this);"></asp:TextBox><asp:NumericUpDownExtender ID="NumericUpDownExtender2" runat="server" TargetControlID="txtActGrams" 
                    Width="20" Minimum="0" TargetButtonDownID="IBtnDown" TargetButtonUpID="IBtnUp"></asp:NumericUpDownExtender><asp:FilteredTextBoxExtender ID="FilteredTextBoxExtender1" runat="server" 
                    TargetControlID="txtActGrams" ValidChars="0123456789."></asp:FilteredTextBoxExtender><asp:RequiredFieldValidator ID="RequiredFieldValidator1" runat="server" 
                    ErrorMessage="Grams are required" ControlToValidate="txtActGrams" 
                    Display="Dynamic"></asp:RequiredFieldValidator></ItemTemplate><FooterTemplate><table><tr><td><asp:Label ID="LblActual" runat="server" Text="Actual"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoal" runat="server" Text="GOAL"></asp:Label></td></tr></table></FooterTemplate><ItemStyle VerticalAlign="Top" /></asp:TemplateField><asp:TemplateField><ItemTemplate><asp:ImageButton ID="IBtnUp" runat="server" ImageUrl="~/images/up.GIF" TabIndex="-1" OnClientClick="setChange();" /><br /><asp:ImageButton ID="IBtnDown" runat="server" ImageUrl="~/images/down.GIF" TabIndex="-1" OnClientClick="setChange();" /></ItemTemplate><ItemStyle VerticalAlign="Top" /></asp:TemplateField><asp:TemplateField HeaderText="Fat" SortExpression="CalcFat" ItemStyle-HorizontalAlign="Left" HeaderStyle-HorizontalAlign="Left"><ItemTemplate><asp:Label ID="LblCalcFat" runat="server" Text='<%# Bind("CalcFat") %>'></asp:Label><asp:Label ID="LblOldFat" runat="server" Text='<%# Eval("CalcFat") %>' CssClass="Hide"></asp:Label><asp:Label ID="LblFoodFat" runat="server" Text='<%# Eval("FoodFat") %>' CssClass="Hide"></asp:Label></ItemTemplate><FooterTemplate><table><tr class="bgyellow"><td><asp:Label ID="LblTotalFat" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalFat" runat="server" Text=""></asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField HeaderText="Pro" SortExpression="CalcPro" ItemStyle-HorizontalAlign="Left" HeaderStyle-HorizontalAlign="Left"><ItemTemplate><asp:Label ID="LblCalcPro" runat="server" Text='<%# Bind("CalcPro") %>'></asp:Label><asp:Label ID="LblOldPro" runat="server" Text='<%# Eval("CalcPro") %>' CssClass="Hide"></asp:Label><asp:Label ID="LblFoodPro" runat="server" Text='<%# Eval("FoodPro") %>' CssClass="Hide"></asp:Label></ItemTemplate><FooterTemplate><table><tr><td class="bgyellow"><asp:Label ID="LblTotalPro" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalPro" runat="server" Text=""></asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField HeaderText="Net Carb" SortExpression="CalcCarb" ItemStyle-HorizontalAlign="Left" HeaderStyle-HorizontalAlign="Left"><ItemTemplate><asp:Label ID="LblCalcCarb" runat="server" Text='<%# Bind("CalcCarb") %>'></asp:Label><asp:Label ID="LblOldCarb" runat="server" Text='<%# Eval("CalcCarb") %>' CssClass="Hide"></asp:Label><asp:Label ID="LblFoodCarb" runat="server" Text='<%# Eval("FoodCarb") %>' CssClass="Hide"></asp:Label></ItemTemplate><FooterTemplate><table><tr><td class="bgyellow"><asp:Label ID="LblTotalCarb" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalCarb" runat="server" Text=""></asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField ItemStyle-HorizontalAlign="Right"><ItemTemplate><asp:Label ID="LblFiberUnknown" runat="server" Text="*" ForeColor="Blue" CssClass="Hide"></asp:Label><asp:CheckBox ID="ckFiberUnknown" runat="server" Checked='<%# Eval("FiberUnknown") %>' CssClass="Hide" /></ItemTemplate><FooterTemplate><table><tr><td class="bgyellow"><asp:Label ID="LblFiber1" runat="server">&nbsp;</asp:Label></td></tr><tr><td><asp:Label ID="LblFiber2" runat="server">&nbsp;</asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField HeaderText="Fiber<br />*=NA" SortExpression="Fiber" ItemStyle-HorizontalAlign="Left" HeaderStyle-HorizontalAlign="Left"><ItemTemplate><asp:Label ID="LblCalcFiber" runat="server" Text='<%# Eval("CalcFiber") %>'></asp:Label><asp:Label ID="LblOldFiber" runat="server" Text='<%# Eval("CalcFiber") %>' CssClass="Hide"></asp:Label><asp:Label ID="LblFiber" runat="server" Text='<%# Eval("Fiber") %>' CssClass="Hide"></asp:Label></ItemTemplate><FooterTemplate><table><tr style="vertical-align: top"><td class="bgyellow"><asp:Label ID="LblTotalFiber" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalFiber" runat="server">&nbsp;</asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField HeaderText="Calories" SortExpression="CalcCal" ItemStyle-HorizontalAlign="Left" HeaderStyle-HorizontalAlign="Left"><ItemTemplate><asp:Label ID="LblCalcCal" runat="server" Text='<%# Bind("CalcCal") %>'></asp:Label><asp:Label ID="LblOldCal" runat="server" Text='<%# Eval("CalcCal") %>' CssClass="Hide"></asp:Label><asp:Label ID="LblIVCarb" runat="server" Text='<%# Eval("IVCarb") %>' CssClass="Hide"></asp:Label></ItemTemplate><FooterTemplate><table><tr><td class="bgyellow"><asp:Label ID="LblTotalCal" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalCal" runat="server" Text=""></asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField HeaderText="Pro+Carb&nbsp;" ItemStyle-BorderStyle="None" HeaderStyle-HorizontalAlign="Left"><ItemTemplate>&nbsp;</ItemTemplate><FooterTemplate><table><tr><td class="bgyellow"><asp:Label ID="LblTotalUnits" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalUnits" runat="server" Text=""></asp:Label></td></tr></table></FooterTemplate></asp:TemplateField><asp:TemplateField HeaderText="Ratio" ItemStyle-BorderStyle="None" HeaderStyle-HorizontalAlign="Left"><ItemTemplate><asp:Label ID="LblFoodID" runat="server" Text='<%# Eval("FoodID") %>' CssClass="Hide">&nbsp;</asp:Label></ItemTemplate><FooterTemplate><table><tr><td class="bgyellow"><asp:Label ID="LblTotalRatio" runat="server" Text="" ClientIDMode="Static"></asp:Label></td></tr><tr><td><asp:Label ID="LblGoalRatio" runat="server" Text=""></asp:Label></td></tr></table></FooterTemplate></asp:TemplateField></Columns></asp:GridView>