Ajax site not working correctly on Remote machine when run from Server 2008 R2.

I've been working on an Ajax site for a while and recently attempted to publish it to a Window Server 2008 R2 server.

The site works correctly on my Devel machine and when run locally on the windows 2008 R2 server, but when I open the site from another machine the page doesn't operate the same way.  Some functionality is lost.

I've looked at the server logs, and an error originally being displayed on the remote machine indicated a Hotfix from MS was required to fix a known issue with the server changing it's password.  I've tried changing the App Pool to NetworkService, and have even allowed delegation on the Server Object.

Is there something else I could try, or somewhere else I should be looked for an error?

Thanks